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TDP-43 (TAR DNA-Binding Protein 43) in ALS
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Biology, Pathology, Assays, and Clinical Biomarker Development Below is an in-depth, technical document on TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis (ALS), including scientific assertions with linked sources, detailed discussion of its biological role, pathology, testing/measurement challenges, and its current and emerging role as a biomarker in diagnosis and disease progression. 1. Molecular…
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Neurofilament Light Chain (NfL) in Amyotrophic Lateral Sclerosis (ALS)
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(Article generated by AI and presented as my best understanding of this very complex topic as of 2/22/26) An in-depth and technically detailed overview of Neurofilament light chain (NfL) in amyotrophic lateral sclerosis (ALS) — including the biological basis, measurement techniques, clinical relevance, and its use in diagnosis and progression tracking, supported with linked scientific…
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ALS Trials & Treatments
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As of 2025, the landscape of clinical trials for amyotrophic lateral sclerosis (ALS) is marked by significant advancements, promising therapies, and a renewed sense of urgency in the scientific community.
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ALS Gear – Ssoooo Much Gear!!
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There are so many assistive devices and tools that you need dealing with ALS. Over the past year, I have accumulated multiple modes of assistive mobility equipment as well as more gear for helping with various day-to-day activities.
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Veterans Law Signed
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The president signed the Senator Elizabeth Dole 21st Century Veterans Healthcare and Benefits Improvement Act into law Jan. 2, after years of advocacy by more than 40 veterans organizations.
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ALS Nexus Conference
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ALS Nexus brings together leaders in the ALS community to connect, collaborate, and change the future of ALS. This is more than a conference – it’s an opportunity to spark new ideas and accelerate progress toward the goal of making ALS a livable disease until we can cure it.
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ALS Center of Excellence
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ALS is a complex disease that requires a significant number of specialists who support their patients. Because of this, there have been numerous ALS centers of excellence created across the United States to offer a unique and all-encompassing medical support team. The term usually associated with this type of care is multidisciplinary or Interdisciplinary both…
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ALS Veteran Risks
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In 2008, the Department of Veterans Affairs (VA) established Amyotrophic Lateral Sclerosis (ALS) as a “service-connected disease,” meaning veterans diagnosed with ALS could receive disability benefits from the VA due to their military service; this effectively acted as the “ALS Veteran Act” for that year, with the announcement made on September 23, 2008. “Military veterans, regardless of…
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